AASC Clinical Research

Helping to usher in a future of better care.

Open Studies

Now Enrolling...

1. The FLAIR Pediatric and Adult Asthma Study

A study to test if a combination of fluticasone propionate/albuterol sulfate is effective in preventing asthma attacks

Purpose

The FLAIR Study is evaluating the effectiveness and safety of a combination of 2 commercially approved drugs, fluticasone (Fp) and albuterol (ABS), in a single inhaler compared to albuterol (ABS) alone for asthma attacks in adults, adolescents, and children with asthma. The study will determine if using the study combination will reduce the occurrence of asthma episodes ("attacks") that require systemic corticosteroids or hospitalizations for treatment.

Important Information:

• During the study, participants will continue taking their usual asthma maintenance medication
• Participants will be in the study for at least 6 months
• The investigational study drug and study procedures are provided at no charge
• Travel and study-related costs may be reimbursed
• There is no placebo arm in this study; participants will receive either the study drug combination or ABS
• The study enrollment is expected to last until approximately the third quarter of 2025

Who Can Join

To participate in this study, you must:

• Be 4 years of age or older
• Be diagnosed with asthma for at least 1 year
• Have had 1 or more severe asthma attacks in the past 12 months

There are also other requirements that will determine who can participate. A doctor will determine if you are medically eligible to take part in this study.

2. The NIMBLE Study

Severe asthma? We’re working to give you more freedom between treatments

The Nimble Study is looking at a possible new medicine (study drug) for people with eosinophilic asthma (a type of severe asthma).

The study will look at how safe the study drug is and whether it works for adults and adolescents with eosinophilic asthma.

You or someone you care for may be able to take part if you/they:

• are at least 12 years of age
• have severe asthma that has been controlled with mepolizumab or benralizumab for at least 12 months.
   

3. The VATHOS Study

The VATHOS study is evaluating if a new investigational inhaler called Budesonide and Formoterol Fumarate (BFF) metered dose inhaler (MDI) may provide benefit for people whose asthma symptoms are not fully controlled using their current inhaler treatment. Researchers will compare BFF MDI against BD MDI (a similar investigational inhaler) and Symbicort® Turbuhaler® (an approved treatment for asthma) to see if it is better, worse, or the same at controlling asthma symptoms. This study will also help us learn more about asthma and other associated conditions.

What Are the Study Treatments?

BFF is an investigational metered dose inhaler (MDI) that sprays a specific combination of the medicines budesonide and formoterol fumarate into the airways. Both of these medicines are already approved to treat asthma, either on their own or in combination with other medicines. The two medicines are designed to work together to reduce inflammation, relax the muscles in the airway, and help keep the airways open.

Two different dose levels of BFF will be compared against: BD, a similar investigational MDI containing only budesonide, and Symbicort® Turbuhaler®, an approved inhaler containing budesonide and formoterol fumarate.

Why Participate?

Before a potential treatment for asthma can be approved, it must first be tested in a series of clinical trials. By choosing to volunteer for this study, you can help us learn more about how the BFF MDI works. The findings from this study may lead to better treatment options and help other people with asthma in the future.

Who Can Participate?

This study may be an option for people who:

• Are 12 to 80 years old
• Have been diagnosed with asthma for at least six months
• Have been using the same low dose of ICS or ICS/LABA (inhaled corticosteroid/long-acting beta agonist) inhaler medication every day for at least eight weeks before their first study visit

There are other requirements to join this clinical study. A study team member will help determine if this study is right for you based on all participation criteria.

Why take part in a clinical research study?

There is no obligation to take part, so see if you qualify!

Those who are eligible may receive:

• Study-related care from local specialists at no cost
• Study medication at no cost
• Compensation for time and study-related travel expenses

Plus you are helping to advance the treatment of asthma!

Interested?

If you're interested in any of the above studies, contact our study coordinator.